The word Autologous means derived from recipient receiving graft.
A stem cell is an unspecified cell that can both self-renew (reproduce itself) and differentiate into mature cells/tissues such as collagen, skin, cartilage, heart, lung, and pancreas.
Stem cells can be collected from peripheral blood or bone marrow.
Peripheral Blood stem cells are easier and less painful to collect than Bone Marrow stem cells.
Peripheral Blood collection also yields more stem cells than bone marrow collection.
Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model
Mitra Lavasani, Andria R. Robinson, Aiping Lu, Minjung Song, Joseph M. Feduska, Bahar Ahani, Jeremy S. Tilstra, Chelsea H. Feldman, Paul D. Robbins, Laura J. Niedernhofer & Johnny Huard
Nature Communications 3, Article number: 608 doi:10.1038/ncomms1611 Received 26 July 2011 Accepted 24 November 2011 Published 03 January 2012
With ageing, there is a loss of adult stem cell function. However, there is no direct evidence that this has a causal role in ageing-related decline. We tested this using muscle-derived stem/progenitor cells (MDSPCs) in a murine progeria model. Here we show that MDSPCs from old and progeroid mice are defective in proliferation and multilineage differentiation. Intraperitoneal administration of MDSPCs, isolated from young wild-type mice, to progeroid mice confer significant lifespan and healthspan extension. The transplanted MDSPCs improve degenerative changes and vascularization in tissues where donor cells are not detected, suggesting that their therapeutic effect may be mediated by secreted factor(s). Indeed, young wild-type-MDSPCs rescue proliferation and differentiation defects of aged MDSPCs when co-cultured. These results establish that adult stem/progenitor cell dysfunction contributes to ageing-related degeneration and suggests a therapeutic potential of post-natal stem cells to extend health.